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免疫检查点阻塞延迟癌症的发展,并延长DNA聚合酶突变症综合征的生存期

Akshada Sawant1,2, Fuqian Shi1, Eduardo Cararo Lopes1

  • 1Rutgers Cancer Institute, Rutgers University, New Brunswick, New Jersey.

Cancer research
|January 9, 2025
PubMed
概括

在DNA聚合酶POLD1和POLE中的突变增加了癌症风险和瘤突变负担 (TMB). 在高风险小鼠中,早期免疫检查点阻塞 (ICB) 能够预防癌症,这表明在风险增加的个体中,癌症预防的潜力.

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