新发性心力衰竭的性别特异性风险因素:在25岁时进行的PREVEND研究
Bart J van Essen1, Johanna E Emmens1, Jasper Tromp2,3
1Department of Cardiology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
European heart journal
|January 9, 2025
概括
男人面临更高的终身心力衰竭风险与减少喷射率 (HFrEF),而女性更容易心力衰竭与保存喷射率 (HFpEF). 可修改的风险因素对这两种情况都有很大影响,特别是在女性身上.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 对心力衰竭 (HF) 亚型,心力衰竭减排分数 (HFrEF) 和心力衰竭保持射出分数 (HFpEF) 的终身风险估计主要基于美国的研究.
- 缺乏欧洲关于性别特异性终身风险的数据,以及发生高频率事件的可修改风险因素的人口归因分数.
研究的目的:
- 为了确定一个大型欧洲队列中发展HFrEF和HFpEF的性别特异性终身风险.
- 评估发生HFrEF和HFpEF的潜在可修改风险因素的可归因人口部分.
主要方法:
- 利用了PREVEND队列中的8558名参与者的数据,并从1997年至2022年进行了随访.
- 通过医院记录识别了新发病的HFrEF (射出分数 < 50%) 和HFpEF (射出分数 ≥ 50%).
主要成果:
- 总体而言,男性的终身HF风险为24.5%,女性为23.3%.
- 男性的HFrEF终身风险较高 (18.1%对11.9%),而女性的HFpEF终身风险较高 (11.5%对6.4%).
- 八种可修改的风险因素占女性HFrEF病例的71%和男性的60%;女性HFpEF病例的64%和男性的46%. 高血压和高胆固醇是HFrEF的关键;高血压和肥胖是HFpEF的关键.
结论:
- 在男性中,HFrEF的终身风险更高,而在女性中,HFpEF的风险更高.
- 可修改的风险因素对HFrEF和HFpEF的发展有显著的贡献,特别是在女性中.
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