相关实验视频

Updated: Jun 3, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

切割胚胎形态和形态动力学是否与产前和新生儿结局有关?

Lucie Rey¹, Julie Barberet^1,2, Lysiane Jonval³

¹Service AMP-Biologique, Institut de La Fertilité, Hôpital François Mitterrand- Université de Bourgogne, Dijon, France.

Journal of assisted reproduction and genetics

|January 9, 2025

概括

胚胎形态学和形态动力学显著影响植入和活产率. 细胞事件的特定时间和前核的出现影响流产风险和出生体重Z分数,突出了它们在辅助生殖中的重要性.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
遗传学遗传学是一个

背景情况:

评估早期胚胎发育对于成功的体外受精 (IVF) 是至关重要的.
形态学和形态动力学参数越来越多地用于选择可行的胚胎.
时隔技术为胚胎发育提供了详细的见解.

研究的目的:

调查切割胚胎形态/形态动力学与产前/产周结局之间的关联.
确定特定的胚胎发育时间是否预测了植入,流产和活产.
评估胚胎质量对出生体重和妊娠期的影响.

主要方法:

在ICSI之后,对734个单次新鲜胚胎移植 (SET) 进行了回顾性队列研究.
胚胎被分类为顶级 (TOP) 或非顶级 (非TOP) 基于使用时差成像的形态/形态动力学标准.
对母体因素进行调整的线性回归分析评估了胚胎质量对各种结果的影响.

主要成果:

非植入胚胎在细胞事件时间 (t2,t3,t4) 和分裂阶段 (ECC1,ECC2) 中显示出显著的偏差.
胚胎形态动力学在非TOP胚胎之间显著不同,导致流产与活产.
短/长胚胎裂解周期1 (ECC1) 与更高的流产风险有关.
晚期前核的出现 (tPNa) 与出生体重增加相关,而晚期前核的消失 (tPNf) 与出生体重较低的Z-分数相关.

结论:

胚胎形态学和形态动力学是植入率和活产成功的重要预测因素.
不理想的胚胎特征会影响成功怀孕的可能性.
特定的前核发育时间 (tPNa,tPNf) 与出生体重Z-score的变化有关.

关键词:

出生时的体重是多少胚胎胚胎是一个胚胎.孕期是一个孕期.美国国务院调查局 (ICSI)形态动力学形态动力学形态学上的形态学.

更多相关视频

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

相关概念视频

Cleavage and Blastulation

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...