在异常性REM睡眠行为障碍和莱维体疾病连续体中轻度行为障碍
Bora Jin1, Eun Jin Yoon2,3, Kyung Ah Woo4
1Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University of College of Medicine, Seoul, Republic of Korea.
轻度行为障碍 (MBI) 与Lewy体疾病 (LBD) 连续患者的疾病严重程度相关. 该MBI检查清单 (MBI-C) 显示了诊断价值在区分认知阶段和预测异常REM睡眠行为障碍 (iRBD) 现象转换风险.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
背景情况:
- 莱维体疾病 (LBD) 连续包括异常REM睡眠行为障碍 (iRBD) 和临床确定的LBD.
- 轻度行为障碍 (MBI) 越来越被认为是神经退行性疾病中显著的临床特征.
- 了解MBI的影响对于评估整个LBD谱的疾病严重程度和进展至关重要.
研究的目的:
- 调查MBI的临床影响和诊断效用,通过MBI检查表 (MBI-C) 评估,在患有LBD连续性的患者中.
- 检查MBI-C得分与临床/认知指标之间的关联,包括疾病严重程度和认知障碍.
- 评估MBI-C在iRBD患者中预测表转换风险的能力.
主要方法:
- 评估了LBD连续体内的84名患者 (35名iRBD,49名LBD).
- 评估包括运动障碍学会统一的帕金森病评级表 (MDS-UPDRS),神经心理测试和MBI检查表 (MBI-C).
- 参与者被分为认知正常 (CN),轻度认知障碍 (MCI) 和痴呆症组.
主要成果:
- 在CN,MCI和痴呆症组中,MBI-C总分数显著增加 (中位数分别为1.0,8.0,18.5;p < 0.001).
- MBI-C评分与MDS-UPDRS评分 (r=0.504-0.508,p < 0.001) 强烈相关,以及前部/执行和注意领域的认知缺陷.
- MBI-C证明了诊断价值,区分MCI与CN (AUC=0.74) 和高风险与低风险iRBD患者 (AUC=0.72).
结论:
- MBI检查清单 (MBI-C) 作为一个有价值的查工具,反映了Lewy体疾病连续性的临床严重程度.
- MBI-C有效地区分认知阶段,并识别在iRBD内具有更高风险的表态转化个体.
- 需要进行进一步的纵向研究,以确定MBI-C在监测前进性LBD疾病进展中的作用.
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