全球批准的COVID-19疫苗:系统审查
Brenda de Almeida Perret Magalhães1,2,3, Jéssica Medeiros Minasi4, Rubens Caurio Lobato5
1Interdisciplinary Group of Virology and Immunology, Faculty of Medicine, Federal University of Rio Grande (FURG), Rio Grande, RS, Brazil. bperret1008@gmail.com.
概括
这次系统性审查分析了已批准的COVID-19疫苗,发现它们通常表现出高效率和安全性. 现实世界的有效性各不相同,一些疫苗的影响低于最初的有效率.
科学领域:
- 病毒学和免疫学 病毒学和免疫学
- 公共卫生和流行病学
- 制药科学 制药科学
背景情况:
- 由于COVID-19的流行,需要快速开发疫苗.
- 了解批准疫苗的特征对于公共卫生战略至关重要.
研究的目的:
- 系统地审查和分析全球批准的COVID-19疫苗的一般特征.
- 总结疫苗的成分,剂量,疗效和不良影响.
主要方法:
- 按照PRISMA指南进行系统审查.
- 搜索了MEDLINE和Web of Science的第三阶段研究 (2020年1月至2023年6月).
- 包括11项关于世卫组织批准的疫苗的研究.
主要成果:
- 所有审查的疫苗都在预防症状性COVID-19方面表现出高效.
- 大多数疫苗都报告了轻度至中度的不良反应.
- 现实世界的有效性各不相同,一些疫苗的有效性低于有效性.
结论:
- 经批准的COVID-19疫苗通常是安全有效的.
- 疫苗的成分,剂量和研究设计都会影响结果.
- 有效性数据可能无法完全预测现实世界的影响.
更多相关视频
12:09Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
Published on: May 2, 2011
42.7K
06:26Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
Published on: July 28, 2023
2.1K
相关概念视频
01:51Vaccinations
44.0K
Overview
44.0K
02:50Conjugated Proteins
18.2K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.2K
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.