吸烟和血液DNA甲基化之间的单向和双向因果关系:基于双胞胎的门德尔随机化的证据
Madhurbain Singh1,2,3, Conor V Dolan4,5, Dana M Lapato6,7
1Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St., Suite 100, Richmond, VA, 23298, USA. singhm18@vcu.edu.
European journal of epidemiology
|January 9, 2025
概括
吸烟对500多个血液部位的DNA甲基化 (DNAm) 有因果影响,影响免疫调节等途径. 一些DNAm网站也影响吸烟行为,揭示了双向链接.
科学领域:
- 遗传学 遗传学 是一个
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 公共卫生 公共卫生
背景情况:
- 吸烟与广泛的DNA甲基化变化有关.
- 之前的孟德尔随机化 (MR) 研究显示,吸烟对DNA甲基化影响的因果关系证据有限.
- 了解因果关系对于解释吸烟相关的健康问题至关重要.
研究的目的:
- 为了研究当前吸烟和血液DNA甲基化之间的因果关系.
- 探索DNA甲基化和吸烟责任之间的潜在双向因果关系.
- 为了利用双胞胎研究设计和先进的统计方法来进行强大的因果推理.
主要方法:
- 综合孟德尔随机化 (MR) 双胞胎因果模型使用来自荷兰双胞胎登记册 (N=2577) 的数据.
- 使用多样性/多基因分数作为仪器变量.
- 控制了潜在的水平向性,并分析了当前的吸烟状态.
主要成果:
- 在500多个地点确定了当前吸烟对DNA甲基化的潜在因果影响.
- 丰富分析显示,受影响的基因与血液形成,神经发育和免疫调节有关.
- 发现了反向和双向因果关系的证据,DNA甲基化可能会影响吸烟责任,特别是在与大脑相关的基因调控元素中.
结论:
- 目前的吸烟因果关系影响了许多血液部位的DNA甲基化.
- DNA甲基化变异可能会影响吸烟责任,表明复杂的双向关系.
- 结合基因型和DNA甲基化数据的双胞胎研究对于健康和疾病研究中的因果推断有价值.
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