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脉冲超声中介药物递送增强通过人类结核

Shuqi You^1,2,3,4, Suqian Wu^1,3,4, Shicheng Yang⁵

¹Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Translational vision science & technology

|January 9, 2025

概括

脉冲超声波 (PUS) 通过暂时增加膜通透性和改善药物储存效应来增强跨膜药物输送. 这种安全高效的方法对将药物输送到眼睛后部有很大的前景.

科学领域:

眼科医生眼科眼科
药物运输药物运输药物运输
生物医学工程生物医学工程

背景情况:

透视性药物输送对于治疗后部眼部疾病至关重要.
当前的方法在有效地穿透膜方面面临着挑战.
脉冲超声波 (PUS) 被探索为一种非侵入性方法,以增强药物透.

研究的目的:

为了研究脉冲超声波 (PUS) 对跨膜药物递送的影响.
描述PUS诱导的膜通透性和药物储存效应的变化.
评估PUS对眼部组织的安全性.

主要方法:

在弗朗茨扩散细胞中使用了人类骨移植,并使用了模型药物 (化和FD-40).
斯克莱拉接受了PUS治疗 (1 MHz,0.71 W/cm2,30%的使用周期,5分钟).
透增强,储效应,组织学和温度变化被评估为ex vivo和in vivo.

主要成果:

单次PUS应用显著增加了FD-40透率.
重复的PUS应用进一步增强了FD-40透率,并显著增加了NaF透率 (超过8.51倍).
PUS暂时改变了膜通透性,增强了储效应,并且在温度升高最小 (<1°C) 并且没有眼睛损伤的情况下是安全的.

结论:

PUS是一种有效和安全的方法,用于增强跨质药物运输.
增强取决于分子大小,并随着重复的PUS应用而增加.
PUS提供了一种概念验证,用于改善向眼睛后部部部位的药物输送.

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