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Updated: Jun 3, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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TAK-994对药物诱导的肝损伤的机制性调查

Tadahiro Shinozawa1, Kazumasa Miyamoto1, Kevin S Baker2

  • 1Takeda Pharmaceutical Company Ltd, Fujisawa, Kanagawa 251-8555, Japan.

Toxicological sciences : an official journal of the Society of Toxicology
|January 9, 2025
PubMed
概括

研究了TAK-994的药物诱导性肝损伤 (DILI),TAK-994是一种素激动剂. 在代谢后的共价结合被确定为特异性DILI的可能原因,这表明剂量降低可能会减轻风险.

关键词:
胆汁盐排放的排放一种共价结合的结合.发现药物的发现.药物诱导的肝损伤是药物诱导的肝毒性 肝毒性 肝毒性

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