由Gemella引起的传染性内心炎 - - 一项基于注册表的回顾性研究
Alla Popova1, Ulrika Snygg-Martin2,3, Magnus Rasmussen1,4
1Division of Infection Medicine, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Infectious diseases (London, England)
|January 9, 2025
概括
由Gemella引起的传染性内心炎是罕见的,但与其他细菌感染具有共同的特征. 更新的杜克-ISCVID 2023标准改善了诊断,而双胞胎内心炎显示出有利的预后.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 感染性内心炎 (IE) 诊断依赖于杜克标准,在2023年更新.
- 杜克-ISCVID 2023标准现在承认Gemella作为一种典型的IE病原体.
- 了解Gemella IE的临床特征是其更新分类后至关重要的.
研究的目的:
- 评估由Gemella物种引起的传染性内心炎的临床特征.
- 将Gemella IE与其他常见病原体引起的IE进行比较.
- 评估杜克-ISCVID 2023标准对双胞胎IE诊断的影响.
主要方法:
- 从瑞典传染性内心炎登记处 (SRIE) 的数据进行了回顾性分析.
- 将Gemella IE的临床特征与由非β血溶性链球菌,金黄色葡萄球菌和肠球菌引起的IE进行比较.
- 使用修改的杜克与杜克-ISCVID 2023标准评估诊断标准的变化.
主要成果:
- 双胞胎IE在SRIE中占所有IE病例的0.4% (29/7677次).
- 最常见的物种是Gemella morbillorum和Gemella bergerii,它们是最常见的物种.
- 根据杜克-ISCVID 2023标准,确定的IE诊断从45%增加到72%.
- 患者年龄较大 (中位数为70岁),主要患有本源IE (90%),死亡率低 (3%).
- 双胞胎IE的临床表现类似于非β血溶性链球菌IE的临床表现.
结论:
- 双胞胎IE是一种罕见的疾病,其临床特征与非β型血液溶解性链球菌IE相似.
- 更新的杜克-ISCVID 2023标准提高了Gemella IE的诊断.
- 双胞胎IE似乎有一个相对有利的预后.
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