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Updated: Jun 3, 2025

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通过托尔类受体适配器TRIF和TRAM进行TIR域介导的先天性免疫信号的结构基础

Mohammad K Manik1,2, Mengqi Pan3,4,5, Le Xiao1,2

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

Proceedings of the National Academy of Sciences of the United States of America
|January 9, 2025
PubMed
概括

研究人员发现了收费类受体 (TLR) 信号适配器TRIF和TRAM的结构基础. 他们的发现揭示了用于天生的免疫信号的统一螺旋丝机制,提供了潜在的治疗点.

关键词:
这是一个MyD88独立的TLR信号.这是一个TIR域名.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.螺旋式重建螺旋式重建

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