Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

472
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
472
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.4K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity.

The Journal of experimental medicine·2026
Same author

Quadratus lumborum block at the lateral supra-arcuate ligament for postoperative analgesia: a protocol for a systematic review and meta-analysis.

Annals of medicine·2025
Same author

Vaccination Strategies and Research Gaps in Hepatitis E Virus for Special Populations.

Vaccines·2025
Same author

Machine Learning Models Based on Enlarged Chemical Spaces for Screening Carcinogenic Chemicals.

Chemical research in toxicology·2025
Same author

Freeze-drying enhances ToF-SIMS imaging of biological tissues <i>via</i> structural and metabolic preservation.

Analytical methods : advancing methods and applications·2025
Same author

Delta/Lambda Chirality: From Enantiomers to Diastereomers in Heterometallic Complexes with Chelating Ligands.

Inorganic chemistry·2025

相关实验视频

Updated: Jun 3, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

280

多TACs:以多个免疫细胞共同参与者向固体瘤.

Yuxuan Zhang1, Zijian Zhang2, Feng Lin1

  • 1Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

ACS chemical biology
|January 9, 2025
PubMed
概括

一个新的多式向嵌合体 (Multi-TAC) 平台使用三重直角链接器 (T-Linker) 来同时激活多个免疫细胞. 这种单剂方法通过管理瘤免疫微环境 (TIME) 来增强瘤向免疫疗法.

更多相关视频

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

639
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

9.5K

相关实验视频

Last Updated: Jun 3, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

280
Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
07:55

Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer

Published on: January 17, 2025

639
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

9.5K

科学领域:

  • 免疫学 免疫学 免疫学
  • 在瘤学瘤学.
  • 生物技术是生物技术.

背景情况:

  • 瘤免疫微环境 (TIME) 包含多样化的免疫细胞,影响癌症免疫治疗结果.
  • 同时管理多种免疫细胞类型与单一的药物是先进的抗瘤免疫的重大挑战.

研究的目的:

  • 介绍一个新的平台,可以在时间内同时针对多种免疫细胞类型.
  • 为了实现单剂介导的,针对瘤的免疫细胞的共同参与,以增强免疫疗法.

主要方法:

  • 基于三重直角链接器 (T-Linker) 的多式模式定位模拟器 (Multi-TAC) 平台的开发.
  • 利用多TAC平台,协调向瘤微环境中的各种免疫细胞群.

主要成果:

  • 多TAC平台促进了多个免疫细胞的单剂介导的共同参与.
  • 这种方法可以通过调节 TIME 来实现瘤向免疫治疗.

结论:

  • 基于T-Linker的多TAC平台为增强癌症免疫治疗提供了一个有前途的战略.
  • 这种创新方法解决了协同管理多个免疫细胞以改善抗瘤反应的挑战.