在静止的克罗恩病患者中降低条件,患者的疲劳感知增加
Jordan J McGing1, Sébastien Serres2, Rosemary Nicholas1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom.
Journal of Crohn's & colitis
|January 9, 2025
概括
患有克罗恩氏病 (CD) 的患者会经历更大的疲劳,这可能与运动期间大脑血流减少和肌肉能量恢复速度减慢有关. 这项研究探讨了在炎症性肠病 (IBD) 中导致疲劳的生理因素.
科学领域:
- 胃肠病学 胃肠病学
- 生理学 生理学 生理学
- 医疗成像医学成像
背景情况:
- 炎症性肠道疾病 (IBD) 的疲劳病因不明.
- 这项研究研究了休眠克罗恩病 (CD) 患者的生理因素.
- 与健康的志愿者进行了比较.
研究的目的:
- 量化CD患者和HV患者的身体组成和身体功能.
- 使用质子磁共振成像 (1H MRI) 和光谱 (31P MRS) 来测量器官结构和功能.
- 为了确定IBD疲劳的生理基础.
主要方法:
- 双能量X射线吸收度和1HMRI用于身体组成.
- 动力测量用于肌肉力量和疲劳.
- 1HMRI用于心脏输出,脑血流 (gmCBF) 和运动期间脑氧提取分数 (OEF).
- 31P MRS用于运动后的肌肉脂蛋白 (PCr) 再合成.
主要成果:
- 慢性病患者报告疲劳感觉更强,每日步数更少.
- 在CD患者在稳定状态运动期间观察到降低的gmCBF.
- 与HV患者相比,CD患者的运动后PCr复合速度较慢.
- 没有注意到身体组成,同位体强度或异位动力疲劳度的显著差异.
结论:
- 在CD患者中,增加疲劳感知与运动后PCr复合缓慢相关.
- 这些发现独立于身体组成,肌肉强度和疲劳能力.
- IBD疲劳可能与周围肌肉脱节和在次最大运动期间减少gmCBF有关.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
315
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
315
Muscle Recovery and Fatigue
2.0K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.0K
Inflammatory Bowel Disease II: Crohn's Disease
183
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
183
Chronic Bowel Disorders: Introduction
386
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
386
Assessment of the Gastrointestinal System II: Health Perception Pattern
75
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
75
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
141
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
141


