用glipizide加载的聚合物微粒的制造;体外和体外评估
Qaiser Rasheed1, Kamran Ahmad Khan1, Ghulam Razaque2
1Gomal Centre of Pharmaceutical Sciences, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
PloS one
|January 9, 2025
概括
使用Eudragit S100和Methocel K 100 M聚合物开发了可控释放的Glipizide微粒. 这些配方表现出持续释放药物12小时,改善了低血糖效应和患者的遵守性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 控制释放药物输送系统的目的是改善患者的服药性,降低剂量频率.
- 格利皮齐德是一种口服低血糖药,用于治疗2型糖尿病.
研究的目的:
- 使用Eudragit S100和Methocel K 100 M设计和描述可控释放的格利皮齐德微粒.
- 评估开发的微粒的药物释放动力学和体内疗效.
主要方法:
- 使用溶剂蒸发方法制造微粒,药物与聚合物的比率各不相同.
- 描述包括流动特性,粒子大小,形态,产量,捕获效率和药物负载.
- 进行了溶解研究和运动建模 (例如,异常的非菲克扩散).
- 活体内研究评估了12小时的低血糖效应.
主要成果:
- 微粒子表现出有利的流量特性,粒子大小分布 (95.3-126微米),高产量 (66-77%),捕获效率 (80-96%) 和药物载荷 (46-54%).
- 所有配方都显示Glipizide持续释放长达12小时,在异常的非Fickian扩散之后.
- 活体内研究证实了持续的低血糖影响12小时.
结论:
- 尤德拉吉特S100和梅索塞尔K 100 M是开发可控释放格利皮齐德微粒的合适聚合物.
- 开发的微粒有效地降低了剂量频率,并显示出改善患者服药性和持续血糖控制的潜力.
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