Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

3.3K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
3.3K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

9.8K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
9.8K
Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

3.5K
Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
3.5K
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry01:28

Diels–Alder Reaction Forming Cyclic Products: Stereochemistry

3.7K
The Diels–Alder reaction is one of the robust methods for synthesizing unsaturated six-membered rings. The reaction involves a concerted cyclic movement of six π electrons: four π electrons from the diene and two π electrons from the dienophile.
3.7K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

1.9K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
1.9K
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction01:26

Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

3.3K
α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
3.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Heterocyclic Surgery for Isotopic Labeling.

Synlett : accounts and rapid communications in synthetic organic chemistry·2026
Same author

Enantioselective Total Synthesis of Two Aromatized Halicyclamines.

Journal of the American Chemical Society·2026
Same author

Substrate-Dependent Hydridic and Radical Reactivity of Triiron Hydride Clusters.

Inorganic chemistry·2025
Same author

Enantioselective total synthesis of (+)-cylindricine B.

Chemical science·2024
Same author

<sup>15</sup>NRORC: An Azine Labeling Protocol.

Journal of the American Chemical Society·2024
Same author

Dearomative Access to (-)-Thebaine and Derivatives.

Organic letters·2023

相关实验视频

Updated: Jun 3, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

9.7K

天然产品总合成中的阿酸脱氧化.

Brian J Knight1, Thiago A Grigolo2, Zachary A Tolchin2

  • 1Department of Medicinal Chemistry, Asha Therapeutics, 3802 Spectrum Blvd. Suite 146, Tampa, FL, 33612, USA.

Chemistry (Weinheim an der Bergstrasse, Germany)
|January 9, 2025
PubMed
概括

类天然产品激发了新的药物. 化学家现在可以高效地从丰富的芳香源中构建复杂的结构,并使用 Dearomatization 策略进行药物发现.

关键词:
类化合物是一种类化合物.亲爱的欧美化 亲爱的欧美化异循环是指异循环的.皮里丁酸盐是什么 皮里丁酸盐总的合成总的合成.

更多相关视频

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
08:56

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

17.2K
Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
13:05

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

Published on: June 28, 2019

8.0K

相关实验视频

Last Updated: Jun 3, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

9.7K
Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
08:56

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

17.2K
Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
13:05

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

Published on: June 28, 2019

8.0K

科学领域:

  • 有机化学 有机化学
  • 药用化学 医学化学
  • 合成化学 合成化学

背景情况:

  • 类天然产品在历史上曾作为关键的药物剂,并继续激发新的治疗开发.
  • 复杂的结构的合成,特别是类化合物,是一个重大的挑战,也是合成化学创新的驱动力.
  • 性芳香化合物是丰富的原料,但它们对化物合成的有效功能化一直是有限的,直到最近的进展.

研究的目的:

  • 总结一下最近在合成策略中取得的进展,用于制造类天然产品.
  • 强调 dearomatization 的实用性,作为有效合成化合物的关键策略.
  • 引导合成化学家在使用 dearomatization 进行以目标为导向和以多样性为导向的合成.

主要方法:

  • 对最近的合成方法进行审查和分析,重点是酸芳香原料的功能化.
  • 评价 dearomatization反应作为化物合成的战略方法.
  • 对比和对比各种合成路径,以评估效率和适用性.

主要成果:

  • 最近反应设计的进步使得丰富的芳香原料可以用于简洁的类化合物合成.
  • Dearomatization 策略为复杂的结构提供了一条强大而有效的途径.
  • 审查的合成证明了 dearomatization 在目标和多样化的分子组装中的多功能性.

结论:

  • 脱氧化代表了类天然产品合成的重大战略进步.
  • 这种方法有助于更高效,更经济地制造有价值的化合物.
  • 鼓励化学家们考虑在药物发现和开发中对未来的合成努力进行 dearomatization.