代谢功能障碍相关的稳态性肝病的心血管风险,心脏代谢风险因子数,以及它们的纵向变化:全国性队列研究
Hyeok-Hee Lee1,2, Han Ah Lee3, Eun-Jin Kim1,2
1Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, South Korea.
The American journal of gastroenterology
|January 9, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 增加了心血管疾病 (CVD) 的风险,特别是更多的心脏代谢因素. 随着时间的推移,MASLD和风险因素的变化也会影响心脏病发病率,指导个性化风险管理.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是与心血管疾病 (CVD) 相关的日益关注的问题.
- 在MASLD人群中,个体心血管疾病风险是可变的.
- 了解MASLD,心脏代谢风险因素和心血管疾病之间的相互作用至关重要.
研究的目的:
- 为了调查MASLD对心血管的影响.
- 评估MASLD患者心脏代谢风险因子数和心血管疾病风险之间的关联.
- 检查MASLD状态和心脏代谢风险因素的纵向变化及其对心血管疾病的影响.
主要方法:
- 利用了来自7,292,497名成年人 (20-79岁) 的全国健康查数据,没有过度饮酒,其他肝病或之前的心血管疾病.
- 根据MASLD状态和心脏代谢风险因子计数 (1-5) 分类参与者.
- 分析了使用多变量调整的Cox模型在12.3年的中位数随访期间发生的CVD风险,考虑到基线和随访数据.
主要成果:
- 存在MASLD与较高的心血管疾病发病率有关.
- 在MASLD患者中,心血管疾病风险随着心脏代谢风险因子数量增加 (HR 1.18每因子) 而增加.
- 发展MASLD增加了心血管疾病风险 (HR 1.28),而回归降低了心血管疾病风险 (HR 0.84);风险因素的变化也改变了心血管疾病风险.
结论:
- MASLD状态,心脏代谢风险因子数和它们的纵向变化是发生心血管疾病的显著预测因素.
- 通过准确识别这些标志物,可以改进与MASLD相关的心血管疾病风险的个性化管理策略.
- 这项研究强调了MASLD的动态性质及其对心血管健康的影响.
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