增加药物使用率超过偶然诊断的炎症性肠病:一个多中心的,病例对照研究
Iago Rodríguez-Lago1, Urko Aguirre2, Jose Luis Cabriada1
1Gastroenterology Department, Hospital Universitario de Galdakao, Biobizkaia Health Research Institute, Galdakao, Spain.
The American journal of gastroenterology
|January 9, 2025
概括
患有炎症性肠病 (IBD) 的患者的亚临床炎症与诊断前几年增加的药物使用有关. 这一发现表明IBD的早期检测有潜力.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,通常在症状出现后被诊断出来.
- 亚临床炎症可能会先于IBD的明显临床表现.
- 早期发现IBD可以导致及时干预和改善患者的治疗结果.
研究的目的:
- 研究无症状IBD患者的亚临床炎症与药物使用模式之间的关联.
- 为了确定是否在无症状个体中增加药物的使用可以作为IBD的早期指标.
- 将无症状IBD患者的药物使用与症状IBD患者和健康对照进行比较.
主要方法:
- 2010年至2021年间被诊断患有性结肠炎或克罗恩病的患者的多中心,回顾性分析.
- 纳入标准:在结肠直肠癌查期间偶然诊断IBD.
- 在无症状IBD患者的药物使用 (心血管,抗寄生虫,肌肉骨,呼吸道,感官器官) 与症状IBD患者和健康的非IBD对照组在诊断前五年进行比较.
主要成果:
- 后来被诊断为IBD的无症状患者在诊断前五年使用各种药物类别的使用量显著增加.
- 增加使用的药物类别包括心血管,抗寄生虫,肌肉骨,呼吸道和感觉器官药物.
- 这种模式表明,在临床诊断之前,系统性炎症的持续时间很长.
结论:
- 在IBD中,亚临床炎症与诊断前几年增加的药物使用有关.
- 药物模式可能表明系统性炎症过程,为早期IBD检测提供了潜力.
- 对前诊断药物使用的进一步研究可以完善IBD的早期诊断策略.
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