Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.5K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Content Gaps and Informational Quality of TikTok and Bilibili Videos on Pit and Fissure Sealing in China: A Cross-Sectional Study.

Oral health & preventive dentistry·2026
Same author

Sodium-Based Battery Component Design: Imitating Lithium or Forging New Paths?

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Analysis of content, quality, and reliability of temporomandibular disorder-related Chinese videos on TikTok and Bilibili: A cross-sectional study.

Medicine·2026
Same author

Endoscopic Transorbital Anterior Clinoidectomy: Surgical Anatomy and Step-wise Technique.

Operative neurosurgery (Hagerstown, Md.)·2026
Same author

The neurovascular unit under siege: Molecular mechanisms and potential drug target for cerebral edema.

Pharmacology & therapeutics·2026
Same author

Hyperglycosylation is a metabolic driver of Alzheimer's disease.

Nature metabolism·2026

相关实验视频

Updated: Jun 3, 2025

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
09:46

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

Published on: April 27, 2017

9.8K

微球3D结构通过机械转导延迟组织衰老.

Ziang Li1, Jincheng Tang1, Liang Zhou1

  • 1Department of Orthopedics, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Soochow, Jiangsu 215000, China.

ACS nano
|January 9, 2025
PubMed
概括
此摘要是机器生成的。

生物仿真微凝促进细胞细胞核的再生,并减少椎间盘退化. 这些工程外细胞矩阵结构增强了细胞活动,并具有用于组织修复的抗衰老特性.

关键词:
这是一个ECM,ECM是ECM.IVD IVD IVD IVD IVD IVD IVD IVD IVD IVD IVD IVD IVD细胞形态细胞形态学机械传导 机械传导衰老是一种老化.

更多相关视频

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
11:28

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

10.2K
Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

5.5K

相关实验视频

Last Updated: Jun 3, 2025

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration
09:46

3D Magnetic Stem Cell Aggregation and Bioreactor Maturation for Cartilage Regeneration

Published on: April 27, 2017

9.8K
3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening
11:28

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

10.2K
Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

5.5K

科学领域:

  • 生物材料科学 生物材料科学
  • 组织工程是组织工程.
  • 细胞生物学 细胞生物学

背景情况:

  • 细胞外基质 (ECM) 在细胞信号传递和组织平衡中起着至关重要的作用.
  • 仿生ECM结构对衰老和退行,特别是核肉质 (NP) 的影响仍然不清楚.
  • 了解细胞对工程ECM的反应对于开发有效的再生疗法至关重要.

研究的目的:

  • 为了研究异型生物材料微凝如何影响核脉 (NP) 细胞行为及其抵消椎间盘 (IVD) 退化潜力.
  • 探索工程ECM调节细胞活动并促进组织修复的机制.

主要方法:

  • 使用物理挤出和受控交叉连接制造异型生物材料微凝 (MicroRod和MicroSphere).
  • 在微凝上培养NP细胞,以评估细胞对齐,增殖和亡.
  • 研究参与NP细胞反应的细胞信号通路 (YAP/TAZ,cGAS-STING).
  • 在体内将MicroRod与NP细胞植入退化的IVD模型中.

主要成果:

  • 在MicroRod结构上,NP细胞表现出对齐的生长,增强的增殖和减少的亡.
  • 细胞反应表明粘附,机械感知和细胞骨重塑,以响应微凝线索.
  • 观察到YAP/TAZ和cGAS-STING通路的激活,这表明它在纠正衰老机制方面发挥了作用.
  • 在体内研究显示,减少了炎症和蛋白酶分泌,并与退化的磁盘中的NP组织再生相结合.

结论:

  • 不同类型的生物材料微凝可以有效调节NP细胞行为,促进组织再生.
  • 机械应力和生物模拟ECM线索对于维持细胞活动和抗衰老作用至关重要.
  • 工程ECM有望开发用于脊椎间盘疾病的抗退行疗法.