在加拿大和中国的中国成年人中,隐藏的血管大脑损伤和认知功能障碍:CAHHM和PURE-MIND研究
Calvin Ke1, Sonia S Anand2, Eric E Smith3
1Department of Medicine, University of Toronto, Canada.
Neurology
|January 9, 2025
概括
居住在中国的中国成年人与加拿大成年人相比,隐藏的血管大脑损伤 (VBI) 和认知功能障碍的发生率显著更高. 环境因素可能在这些差异中发挥作用,超出了教育和传统的风险因素.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 隐性脑血管疾病的患病率各不相同,但原因尚不清楚.
- 种族差异与其他因素之间的差异仍然是有争议的.
- 研究检查了居住国家对中国成年人的大脑健康的影响.
研究的目的:
- 评估居住国 (加拿大与中国) 与隐藏的血管大脑损伤 (VBI) 之间的关联.
- 检查居住国家和认知功能障碍之间的关联.
- 调查导致VBI和认知功能的差异的因素.
主要方法:
- 在加拿大和中国对40至80岁的中国成年人进行横截面研究.
- 共同主要的结局:隐藏的VBI (MRI定义) 和认知功能障碍 (蒙特利尔认知评估[MoCA]得分<26).
- 一般化的线性模型用于分析关联,调整共变量.
主要成果:
- 加拿大参与者的隐性VBI和认知功能障碍的患病率低于中国的参与者.
- 在中国生活与隐蔽VBI (调整后) 的几率增加了6倍.
- 在中国生活与认知功能障碍的几率增加了7倍 (未经调整).
结论:
- 居住的国家对中国成年人中VBI和认知功能障碍的流行有重大影响.
- 由教育和风险因素解释的认知功能障碍差异.
- 这些因素部分解释了VBI差异,这表明环境影响.
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