在减肥干预期间,SLC16A1 (MCT1) 基因多态与身体组成变化的关联:随机试验与性别依赖分析
Rocío Cupeiro1, Pedro J Benito1, Teresa Amigo2
1LFE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Science (INEF), Universidad Politécnica de Madrid, Madrid, Spain.
概括
SLC16A1 (MCT1) 基因多态性与超重/肥胖个体的身体组成变化有关,特别是遵循运动建议的女性. 监督训练可能会抵消对减肥的遗传倾向.
科学领域:
- 遗传学和运动生理学
- 肥胖问题研究研究
- 代谢适应的过程
背景情况:
- 单碳酸盐运输体 (MCTs) 在运动期间影响能量恒温和新陈代谢.
- 该SLC16A1 (MCT1) 基因编码了一个关键的单碳酸盐输送体.
- 在MCT1的遗传变异可能会影响身体的组成和对减肥干预措施的反应.
研究的目的:
- 为了研究SLC16A1 (MCT1) Asp490Glu (rs1049434) 多态和身体组成的变化之间的关联.
- 检查这种关联中潜在的性别特异性差异.
- 评估基因型和运动干预措施对超重或肥胖个体体构成的相互作用.
主要方法:
- 一项为期6个月的随机对照试验,涉及173名参与者 (超重/肥胖).
- 参与者被分配到监督运动组或身体活动 (PA) 建议组.
- 进行了SLC16A1 (Asp490Glu) 多态 (Asp/Asp,Asp/Glu,Glu/Glu) 的基因型定型和ANCOVA分析.
主要成果:
- 观察到显著的基因型效应和基因型 × 组相互作用,特别是在女性中.
- 在PA推组中的Asp/Asp (TT) 雌性在脂肪质量,体脂百分比和体重方面表现出更大的减少.
- 与Glu/Glu (AA) 雌性相比,Asp/Asp (TT) 雌性经历了更大的瘦体质量减少,而男性在瘦体质量变化中表现出性别差异.
结论:
- SLC16A1 (MCT1) 多态性与身体组成的变化有关,特别是在响应运动建议的女性身上.
- 监督的运动训练可能对减轻与减肥有关的遗传倾向至关重要.
- 瘦体质量反应的性别特异性表明,在肥胖干预中,遗传学和运动之间存在复杂的相互作用.
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