相关实验视频
Updated: Jun 3, 2025

06:09
An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
10.5K
城市公园的生物废物作为新的抗糖尿病药物的可持续来源
Marijan Marijan1, Lejsa Jakupović1, Lovorka Vujić2
1University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Pharmacognosy 10000 Zagreb, Croatia.
Acta pharmaceutica (Zagreb, Croatia)
|January 9, 2025
概括
来自六家工厂的城市公园生物废物,当用50%的乙醇提取时,显示出显著的抗糖尿病特性. 这些植物提取物有效地抑制碳水化合物降解,并具有抗氧化和抗炎作用,这表明它们是天然抗糖尿病产品的宝贵来源.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 城市公园的生物废物中含有丰富的有机植物物质,其经济潜力未得到充分利用.
- 几种常见的中欧城市公园植物含有生物活性化合物.
- 植物提取物的抗糖尿病特性对自然产品开发具有重大意义.
研究的目的:
- 选六种常见的城市公园植物的提取物,以检测它们的抗糖尿病和相关性质.
- 为了确定关键的植物化学物质,负责观察到的生物活性.
- 为了评估不同度的乙醇用于代谢物提取的有效性.
主要方法:
- 植物提取物使用10%和50%的乙醇制备.
- 使用高性能液体染色学 (HPLC) 和UV-Vis光谱光度学进行了植物化学分析.
- 生物活性查包括抗氧化剂测定 (DPPH,ORAC,β-胡卜素-林诺酸,降低功率),酶抑制 (脂氧酶,原酶,α-氨酶,α-葡萄糖酶) 和蛋白质凝固抑制.
主要成果:
- 通过HPLC和UV-Vis分析证实了咖啡酸,奎尔素,黄素和阿比基宁衍生物的存在.
- 提取物在多个测试中显示出显著的抗氧化活性.
- 提取物有效地抑制了碳水化合物降解酶,50%的乙醇提取物显示出更高的疗效,与阿卡尔相比,对α-氨酶和α-葡萄糖酶的抑制.
- 还观察到抑制了脂氧酶,原酶和卵蛋白凝血.
结论:
- 城市公园的生物废物是提取具有抗糖尿病潜力的生物活性化合物的有希望的来源.
- 50%的乙醇是从这些植物物种中提取抗糖尿病代谢物的最佳方法.
- 鉴定的植物提取物为开发抗糖尿病产品提供了天然替代品.
相关概念视频
Bioremediation
18.2K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.2K
Oral Hypoglycemic Agents: Biguanides and Glitazones
165
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
165
Glucagon-like Receptor Agonists
295
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
295
Overview of Metabolism
29.5K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
29.5K

