在韩国人口中使用Y-STR区分父子对的RMplex系统的评估
Ju Yeon Jung1, Eunhye Kim2, Yeon Woo Song3
1DNA Analysis Division, National Forensic Service Seoul Institute, Seoul, South Korea; Department of Forensic Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Forensic science international. Genetics
|January 9, 2025
概括
该RMplex系统有效地通过快速突变的Y-STR位点来区分与父亲相关的男性. 这种新系统显示,与以前的方法相比,韩国父子对的分化率是以前的10倍.
科学领域:
- 法医遗传学 法医遗传学
- 人口遗传学 人口遗传学
- 人类遗传学 人类遗传学
背景情况:
- 快速突变的 (RM) Y染色体短串重复 (Y-STRs) 对于区分父系相关的雄性有价值.
- 该RMplex系统包含26个RM和4个快速突变 (FM) 位点,针对44个男性特有的位点.
研究的目的:
- 评估RMplex系统在韩国人口中的有效性.
- 估计韩国父子对中的Y-STR突变率和差异化率.
- 为了评估非相关的韩国男性的遗传群体值.
主要方法:
- 分析了542对韩国父子夫妇和409名与韩国无关的韩国男性.
- 估计Y-STR突变率和基因多样性值.
- 评估RMplex系统的差异化能力.
主要成果:
- RMplex通过至少一个突变区分了50.7%的父子对,比PowerPlex® Y23系统增加了十倍.
- 平均突变率为2.3 × 10−2,位置特异性速率从1.8 × 10−3到1.1 × 10−1.1不等.
- 对于无血缘关系的男性来说,哈普洛型区分能力为100%,在基因位点上具有很高的基因多样性,特别是DYF1000 (0.9970).
- DYS712在韩国人群中显示出最高的突变率,这表明东亚人群的频率更高.
结论:
- 韩国RMplex系统非常适合在韩国人口中区分与父亲相关的男性.
- 在东亚人中DYS712的高突变率需要进一步调查.
- 虽然多副本的位置增加了歧视,但由于潜在的重复,它们的解释需要谨慎.
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