在下肢损失的个体中植入的神经接口的长期性能和稳定性
Eileen Petros1,2, Michael Miller2, Jeremy Dunning2
1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States of America.
Journal of neural engineering
|January 9, 2025
概括
高密度的神经手恢复下肢截肢者的感觉. 设计修改,比如更小的连接器和更长的导线,在五年内显著改善了神经接口性能.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 康复技术 康复技术 康复技术
背景情况:
- 高密度的神经袖子使下肢截肢者能够恢复体感.
- 改善功能结果包括平衡,步态对称和地形导航.
- 由于关节运动和肌肉活动,在下肢部署神经接口存在挑战.
研究的目的:
- 在肢体丧失的个体中描述外围神经接口的长期性能.
- 确定设计修改,以优化神经接口的功能.
- 为未来的设计提供信息,以提高耐用性和有效性.
主要方法:
- 在五年内对四名跨肢截肢者进行了16接触神经袖口的纵向评估.
- 评估关键的结果措施,包括传感值的电荷密度和电阻.
- 道响应的分析 (一致,部分,不响应).
主要成果:
- 在158个道中,有63%的道持续响应,33%的道部分响应,4%的道没有响应.
- 较小的连接器组件和在袖口附近增加的引线长度显著提高了性能.
- 与早期的参与者 (50%和6%) 相比,后期的参与者表现出更好的反应 (77%和96%持续响应).
结论:
- 植入的神经袖子在活跃个体的残余四肢中表现出强大的稳定性.
- 减少对组件过渡点压力的策略显著提高了整体系统性能.
- 长期表征对于优化用于肢体损失康复的神经接口设计至关重要.
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