忽视症状与ipsilesional空间中的预测过敏性有关
Simone Vossel1, Anne-Sophie Käsbauer2, Paola Mengotti2
1Cognitive Neuroscience, Institute of Neuroscience & Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany; Department of Psychology, Faculty of Human Sciences, University of Cologne, Cologne, Germany.
概括
患有右半球中风的患者表现出过度的响应适应预测,特别是对于ipsilesional刺激,这与空间疏忽症状相关. 这种过敏性与大脑通路断路有关.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经学 神经学
背景情况:
- 空间疏忽,脑损伤后的缺陷,涉及到复杂的认知机制,尚未完全理解.
- 以前的研究表明,忽视患者和右半球 (RH) 卒中幸存者的预测和预测错误反应发生了变化.
- 右角-角结 (rTPJ) 涉及到预测依赖的注意力,并且在忽视时经常受到影响.
研究的目的:
- 研究RH损伤和忽视的患者的改变预测依赖注意力.
- 用计算模型和参与者评分来评估改变暗示预测值的推断.
- 探索预测处理,损伤解剖学和神经心理学表现之间的关系.
主要方法:
- 在RH患者,左半球 (LH) 患者和健康对照中采用空间暗示范式,具有动态暗示目标突发事件.
- 利用Rescorla-Wagner学习模型分析响应时间 (RT) 和参与者对预测价值的评分.
- 检查了计算参数,评分,神经心理测试和损伤连接之间的损伤侧依赖性相关性.
主要成果:
- 没有发现预测推理缺陷的证据.
- RH患者表现出RTs对推断的ipsilesional刺激预测的过敏性,与忽视严重程度相关.
- 尽管有忽视症状,RH患者对暗示预测值的评级与实际值偏离更多.
- 对于异位目标的RT过敏性与前额头 - 双肩,前额头 - 头和前额头 - 双肩通路的断裂有关.
结论:
- 改变预测依赖的处理,特别是夸张的响应适应ipsilesional刺激的预测,在空间忽视中起作用.
- 在RH中风患者中,大脑通路的断开有助于改变预测处理的行为特征.
- 这些发现提供了对空间疏忽和注意力的神经机制的新见解.
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