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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

54
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

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Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
59
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

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Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
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多层网络的不稳定性是精神分裂症患者持续的听觉语言幻觉的基础.

Jinguang Li1, Jingqi He2, Honghong Ren3

  • 1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China; Department of Psychiatry, Wuhan Mental Health Center, Wuhan, PR China.

Psychiatry research
|January 9, 2025
PubMed
概括

动态大脑网络的变化,特别是默认模式网络的切换减少,与精神分裂症 (SCZ) 的听觉语言幻觉 (AVH) 有关. 这些变化可能会导致AVH的持续性.

关键词:
听觉语言幻觉 听觉语言幻觉默认模式的网络模式是默认模式.多层网络是多层网络.精神分裂症是一种精神分裂症.转换率的转换率是什么

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科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 脑部成像 脑部成像

背景情况:

  • 精神分裂症 (SCZ) 的听觉语言幻觉 (AVH) 与大脑网络异常有关.
  • 以前的静态fMRI研究通常假定网络稳定性,限制了对AVH动态变化的理解.

研究的目的:

  • 调查SCZ患者的动态大脑网络变化,包括持久性AVH.
  • 探索网络切换动态和AVH严重程度之间的关系.

主要方法:

  • 分析了60名患有持续性AVH的SCZ患者 (p-AVH),39名没有AVH的SCZ患者 (n-AVH) 和59名健康对照者的静止状态fMRI数据.
  • 利用图形理论和多层模块化来构建和分析时间变化的大脑网络模块化结构.
  • 在不同组中比较全球,子网络和节点网络切换率,并将它们与AVH严重程度相关联.

主要成果:

  • 精神分裂症组表现出比HCs更高的皮下网络切换率,在两组患者中都增加了thalamic节点切换.
  • 与HC和n-AVH组相比,p-AVH组在默认模式网络 (DMN) 和高级额头结中表现出较低的切换率.
  • 在p-AVH组中,DMN切换率与AVH严重程度之间观察到负相关性.

结论:

  • 大脑网络的动态变化,特别是DMN和额头区域的切换减少,可能在SCZ中AVHs的发展和持续性中发挥作用.
  • 这些发现强调了在理解和潜在治疗AVH时考虑网络动态的重要性.