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Updated: Jun 3, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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伊塔科纳酸通过GLO1的蛋白质体降解来驱动促炎反应

Lulu Bai1, Hanghui Yu1, Yiqing Cai1

  • 12nd Ward of Oncology Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130031, China.

Biochemical and biophysical research communications
|January 9, 2025
PubMed
概括

伊塔科纳酸,一种与炎症相关的代谢物,令人惊的是,通过降解氧酶1 (GLO1) 来促进炎症. 这导致有害的甲基醇 (MGO) 积累,在新的研究中恶化了败血症的结果.

关键词:
在 ACOD1 中,ACOD1 是 ACOD1.阿格尔 (Ager) 是一个城市.降解降解是一种降解.在 GLO1 中,GLO1 包含了 GLO1 的元素.炎症 炎症是一种炎症.巨细胞是一个巨细胞.这就是 itaconate.

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