自伤青少年的情绪调节:两个电路的故事
Carmen Santana-Gonzalez1, Janani Ranatunga1, Giang Nguyen1
1Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
Psychiatry research. Neuroimaging
|January 9, 2025
概括
非自杀自伤 (NSSI) 的青少年在情绪调节 (ER) 网络中表现出明显的脑活动. 这些发现揭示了NSSI的潜在生物标志物和未来治疗的目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 非自杀性自我伤害 (NSSI) 与独特的情绪调节 (ER) 网络活动有关.
- 了解这些神经机制对于为患有NSSI行为 (NSSIB) 的青少年开发有效干预措施至关重要.
研究的目的:
- 调查NSSIB青少年与健康对照者在激发情绪的任务中ER网络连接的差异.
- 为了确定与NSSIB频率和缓解相关的神经相关物.
主要方法:
- fMRI用于检查30名患有NSSIB的青少年和30名健康对照者的大脑活动.
- 参与者从事被动观看和积极情绪调节 (ER) 任务,涉及中性,积极,负面和自我伤害图像.
- 分析了大脑区域之间的连接,包括杏仁体和腹条纹体 (VS).
主要成果:
- 患有NSSIB的青少年在自我伤害图像的ER期间表现出桃体-前和下叶 (IPL) 连接性增加,与NSSI频率相关.
- 在自我伤害和积极图像的ER期间,NSSI年轻人观察到增加了与状回环和副海马体的VS连接性,与NSSI频率和缓解有关.
- 这些连接模式表明NSSIB的情绪调节和潜在的基于奖励的学习机制存在困难.
结论:
- 杏仁体和VS电路中明显的ER网络变化与青少年的NSSIB有关.
- 这些发现突出了NSSIB潜在的神经生物标志物,并确定了治疗干预的有希望的目标.
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