循环中的阿佩林水平未能将老年人与肉症相关的肌肉参数联系起来
Eunhye Ji1, So Jeong Park1, Il-Young Jang2
1Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
The journal of nutrition, health & aging
|January 9, 2025
概括
循环中的阿佩林水平似乎不是老年人肉症的可靠生物标志物. 这项研究发现,在人类中,阿佩林和肌肉健康指标之间没有显著的关联.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
背景情况:
- 在临床前模型中,阿佩林在改善肌肉新陈代谢方面表现有前途.
- 以前的研究表明,阿佩林可能对肌肉恒温有保护作用.
研究的目的:
- 研究循环阿佩林水平作为人类肌肉健康的生物标志物的作用.
- 为了评估血清阿佩林和老年人肉症之间的关联.
主要方法:
- 对237名居住在社区的老年人 (≥65岁) 进行横截面研究.
- 使用亚洲特有的标准诊断的肉类症.
- 血清阿佩林度通过酶免疫试验测量.
主要成果:
- 在sarcopenic和非sarcopenic个体之间,血清阿佩林没有显著差异.
- 血清阿佩林与肌肉质量,力量或身体表现没有显著的相关性.
- 阿佩林水平与肉症风险或肌肉表型无关.
结论:
- 在动物模型中观察到的阿佩林对肌肉代谢的有益影响可能不会转化为人类.
- 在临床环境中,血清阿佩林不太可能是沙科佩尼亚的可靠生物标志物.
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