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交通相关空气污染 (TRAP) 暴露,肺功能,呼吸道炎症和呼吸道微生物群:一个随机交叉研究

Rongrong Xu¹, Yanping Zhang², Tingting Wu¹

¹College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

Ecotoxicology and environmental safety

|January 9, 2025

概括

与交通有关的空气污染 (TRAP) 改变了肺部微生物和新陈代谢,影响呼吸系统健康. 在道路上暴露于挥发性有机化合物 (VOC) 是一个关键因素,为TRAP提供了新的见解.

科学领域:

环境健康环境健康
微生物学微生物学
肺部病理学肺部病理学

背景情况:

与交通有关的空气污染 (TRAP) 与呼吸系统疾病有关.
人们越来越认识到肺微生物在呼吸系统健康和疾病中的作用.
关于TRAP对肺微生物群的特定影响的研究有限.

研究的目的:

调查TRAP短期暴露对健康成年人的呼吸健康和肺微生物群的影响.
在TRAP中识别影响呼吸系统参数和微生物组成的特定空气污染物.
通过肺微生物新陈代谢的改变,探索将TRAP暴露与呼吸系统疾病联系在一起的潜在机制.

主要方法:

一项随机交叉研究,涉及35名健康成年人,在道路和公园环境中暴露于TRAP2小时.
测量空气污染物 (PM,NO2,CO,VOC),肺功能,部分排气的氧化 (FeNO) 和肺微生物群.
应用线性混合效应模型来分析TRAP暴露和健康结果之间的关联.

主要成果:

与公园暴露相比,道路暴露显示出NO2,CO和VOC度更高.
升高的FeNO与高TRAP暴露有关,但肺功能没有显著变化.
单独的Lentilactobacillus和Haepmophilus的丰度与PEF和FeNO的变化相关.
与转录,氨基酸和碳水化合物代谢相关的丰富途径因TRAP暴露而改变.

结论:

挥发性有机化合物 (VOC) 被确定为一个重要的空气污染物,有助于TRAP的呼吸系统影响.
暴露于TRAP,特别是VOC,可以改变肺部微生物的新陈代谢,可能有助于呼吸系统疾病的发展.
这项研究提供了一种基于微生物组的新机制,以了解与交通有关的空气污染对呼吸道的影响.

关键词:

肺部的微生物群.随机交叉试验随机交叉试验呼吸系统的影响与交通有关的空气污染与交通有关的空气污染.

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