对外耳进化的基因调节程序的重新使用
Mathi Thiruppathy1, Lauren Teubner1, Ryan R Roberts1
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Nature
|January 9, 2025
概括
哺乳动物的外耳是通过与鱼共享的基因调节程序进化而来的. 这项研究揭示了古代遗传途径的进化重复利用,
科学领域:
- 进化发育生物学
- 比较基因组学
- 哺乳动物的进化
背景情况:
- 由于缺乏其软骨结构的化石证据,哺乳动物外耳的进化起源尚不清楚.
- 之前的研究已经揭示了中耳从鱼骨进化, 但外耳的发展仍然是.
研究的目的:
- 调查哺乳动物外耳的进化起源,特别是它是否出现了 de novo 或通过祖先的发展计划的重新定位.
- 确定外耳和其他脊椎动物结构的共同遗传和调节机制.
主要方法:
- 对人类外耳和斑马鱼进行比较单核多组学分析.
- 使用转基因方法识别和功能验证保存的基因表达模式和增强剂.
- 马书的单细胞多组学,以探索无脊椎动物的发育程序.
主要成果:
- 在人类外耳和斑马鱼之间发现了保存的基因表达和调节元素.
- 转基因实验表明人类外耳和鱼之间保持增强剂活性,反之亦然.
- 在脊椎动物和马书中发现了一个共享的远程无同位体 (DLX) 介导的发育程序.
结论:
- 哺乳动物的外耳很可能是通过最初用于祖先脊椎动物部发育的基因调节程序的选择进化而来的.
- 一个古老的无脊椎动物部发育程序的元素被顺序地重新使用,以形成脊椎动物的部,随后是哺乳动物的外耳.
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