库辛病的药理治疗方面的进展'
Jinbao Chai1,2, Yu Tang3, Yuke Liu3
1Department of Endocrinology &Metabolism, West China Hospital, Sichuan University, Chengdu 610041. caijingbao@163.com.
概括
库辛病是一种罕见的内分泌疾病,导致皮质醇过多,当手术不可行时,需要药理治疗. 目前的药物向激素合成或受体,新的药物正在开发中,提供了改进的治疗方法.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 库辛氏病是一种罕见的内分泌疾病,导致过高皮质醇.
- 慢性上升的皮质醇水平会对多个器官系统产生负面影响,影响生活质量并带来危及生命的风险.
- 手术是主要的治疗方法,但对于特定的患者群体,药理选择至关重要.
研究的目的:
- 审查目前对库辛病的药理治疗方法.
- 讨论现有的药物类别及其作用机制.
- 为了突出正在进行的研究和新药开发的库辛病.
主要方法:
- 关于库辛病药物治疗的当前医学文献的综述.
- 现有药物的分类基于它们的治疗标 (垂体ACTH抑制,上腺类固醇生成抑制,葡萄糖皮质体受体对抗作用).
- 目前正在临床试验中的药物的鉴定,用于库辛病.
主要成果:
- 使用的药物主要分为三个类别:索马托斯塔丁/多巴胺受体剂,上腺向剂和葡萄糖皮质体受体对抗剂.
- 其中的例子包括沙利西,卡伯戈林,基托可纳,米特拉,米托坦,奥西洛德罗斯塔特和米费普里斯顿.
- 几种新型药物 (seliciclib,CRN04894,fimepinostat,vorinostat,SPI-62) 正处于II期临床试验阶段.
结论:
- 当手术不是一种选择时,药物治疗对于管理库辛病至关重要.
- 现有的治疗方法提供了各种机制来控制高皮质醇症.
- 对新型药物的持续研究有望为库辛病提供更有针对性,更有效的未来治疗方法.
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