对2名携带不同新型ALK融合的非小细胞肺癌患者的alectinib治疗
Qingchun Liang1,2, Namei Li3,4, Xiaohong Li5,6
1Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011. 503079@csu.edu.cn.
在非小细胞肺癌 (NSCLC) 患者中发现了新型的形淋巴瘤激酶 (ALK) 基因融合,PNPT1-ALK和TCEAL2-ALK. 在这两种情况下,alectinib治疗导致了显著的瘤减少和超过一年的无进展生存.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 无细胞淋巴瘤激酶 (ALK) 基因融合是非小细胞肺癌 (NSCLC) 的关键标.
- 识别新的ALK融合对于扩大向治疗选择至关重要.
研究的目的:
- 在NSCLC患者中报告两种不同的新型ALK基因融合,PNPT1-ALK和TCEAL2-ALK.
- 为了评估alectinib在患有这些罕见ALK融合的患者的治疗疗效.
主要方法:
- 瘤组织的组织病理和免疫组织化学 (IHC) 检查.
- 下一代测序 (NGS) 用于识别基因融合.
- 放大阻燃突变系统 (ARMS) -PCR用于确认.
- 对alectinib治疗反应的临床评估.
主要成果:
- 两名患有肺腺癌的NSCLC患者被发现患有新型ALK融合:PNPT1-ALK (案例1) 和TCEAL2-ALK (案例2).
- 两名患者在接受alectinib治疗后都实现了部分反应,并显著缩小了瘤.
- 两名患者的无进展生存时间都超过了一年.
结论:
- PNPT1-ALK和TCEAL2-ALK是NSCLC中的可操作的融合变体.
- 阿列克提尼布在患有这些新型ALK融合的患者中表现出有利的结果.
- 这项研究有助于了解ALK的融合多样性,并支持ALK氨酸激酶抑制剂精密疗法.
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