晚期胃癌激进手术后系统炎症和营养指数的性别差异
Jincong Min1, Ting Liu2, Mimi Tang3
1Department of Gastrointestinal Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha 410008. 870927387@qq.com.
概括
术后预后营养指数 (PNI) 影响晚期胃癌 (GC) 患者的生存率. 性别特定的营养和炎症标志物,如男性的白蛋白-球蛋白比率 (AGR) 和女性的血小板-淋巴细胞比率 (PLR),也会影响GC预后.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 营养科学 营养科学
背景情况:
- 胃癌 (GC) 的预后受到营养和炎症标志物的影响.
- 专-球蛋白比率 (AGR),预后营养指数 (PNI) 和血小板与淋巴细胞比率 (PLR) 是已确定的预后因素.
- 这些标志物的性别特异性差异可能会影响它们在GC中的预后值.
研究的目的:
- 调查GC患者进行激进手术的营养和炎症指标的预后影响.
- 探索性别对这些指标预后价值的影响.
- 为了确定晚期GC存活的独立预后因素.
主要方法:
- 从2012年1月到2016年12月对596名晚期GC患者的分析.
- 接收器操作特征 (ROC) 分析,以确定关键因素的截止值.
- 多变量和卡普兰-梅尔分析以确定独立的预后因素.
主要成果:
- 手术后的瘤结节转移 (pTNM) 阶段,低的术前AGR和术后PNI是男性GC患者生存的风险因素.
- 对于女性GC患者,pN2-3,全胃切除术,低术前PLR和术后PNI被确定为危险因素.
- 术后PNI成为所有晚期GC患者整体存活的重要风险因素.
结论:
- 手术后的PNI是晚期GC的独立风险因素.
- 手术前的AGR是专门针对男性患者的预后因素.
- 手术前的PLR是专门针对女性患者的预后因素,突出了GC预后的性别特异性差异.
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