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Updated: Jun 3, 2025

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

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选择基因用于分析,使用历史上的偶然进步:从RNA变化到蛋白质-蛋白质相互作用.

Farhaan Lalit1, Antony M Jose1

  • 1University of Maryland, 4066 Campus Drive, College Park, MD 20742, USA.

Nucleic acids research
|January 9, 2025
PubMed
概括

研究人员开发了一种新方法,以优先考虑生物研究中研究不足的基因. 这种方法使用Caenorhabditis elegans中的RNA沉默来识别关键的基因调节器及其相互作用,简化科学发现.

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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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