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基于铁的纳米材料用于调节瘤微环境.

Le Wang1,2,3, Xiaoting Zhang2,3, Lulu He2,3

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概括

基于铁的纳米材料 (IBNMs) 通过改变瘤微环境 (TME) 在癌症治疗中表现有前途. 本综述详细介绍了IBNMs,包括基于氧化铁的纳米材料 (IONMs),如何调节TME以改善癌症治疗结果.

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术 纳米技术
  • 在瘤学瘤学.

背景情况:

  • 基于铁的纳米材料 (IBNMs) 具有独特的磁性,生物相容性和多种功能,使其在生物医学中具有价值.
  • 通过调节瘤微环境 (TME),IBNMs因其在癌症治疗中的潜力而越来越受认可.

研究的目的:

  • 审查各种类型的IBNM,包括基于氧化铁的纳米材料 (IONM),基于铁的复杂合物 (ICC) 和基于铁的单个铁原子纳米材料 (ISANM).
  • 强调IBNMs在调节癌症治疗TME方面的优势.
  • 总结基于IBNM的癌症诊断和治疗策略的最新进展,以TME调制为目标.

主要方法:

  • 关于IBNM及其在癌症治疗中的应用的文献综述.
  • 分析IBNM调节TME的机制,包括克服缺氧,改变酸度,减少氧化还原物种和免疫调节.
  • 讨论TME调节IBNMs领域的挑战和未来机遇.

主要成果:

  • 各种IBNM,如IONM,ICC和ISANM,已经通过TME调节在癌症治疗中表现出显著的能力.
  • IBNMs可以有效地克服瘤缺氧,调节TME酸度,减少有害的氧化还原物种,并促进免疫调节.
  • 最近的进展突显了IBNMs在通过战略调节TME来诊断和治疗癌症方面的潜力.

结论:

  • 通过准和调节TME,IBNM为开发下一代癌症疗法提供了一个有前途的平台.
  • 进一步的研究和开发对于优化IBNM在临床环境中的设计和应用至关重要.
  • 本综述提供了对TME调节IBNMs的未来设计和开发的见解,以提高癌症治疗效率.