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性激素依赖性宿主-微生物群相互作用和心血管风险 (XCVD):纵向多奥米克队列研究的设计

Kristina Franz^1,2,3,4,5, Lajos Markó^6,2,3,5,7, Anja Mähler^6,2,5

¹Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany kristina.franz@charite.de.

|January 9, 2025

概括

该XCVD研究揭示了肠道微生物组如何调解性激素对跨性别个体心血管疾病 (CVD) 风险的影响. 结果提供了对特定性别心血管疾病发展和预防策略的见解.

科学领域:

微生物组研究的研究.
心血管疾病的研究研究.
内分泌学在内分泌学.

背景情况:

心血管疾病 (CVD) 在男性和女性中表现不同,受宿主微生物群相互作用的影响.
性激素,肠道微生物组和心血管疾病结果之间的相互作用仍然不太清楚.
该XCVD研究调查了肠道微生物组在调解性激素对心血管疾病风险标志物的作用中的作用.

研究的目的:

检查肠道微生物组调解性激素对心血管疾病风险标志物的影响.
了解内分泌环境的变化如何影响心血管疾病风险.
从跨性别人群推断到 cisgender 人群的研究结果.

主要方法:

观察性,纵向队列研究,涉及接受性别肯定激素治疗 (GAHT) 的跨性别参与者.
综合的表型化,微生物组基因型化 (16S rRNA,中枪转基因组学),以及血液/头发分析 (性激素,心血管疾病标志物,皮质醇).
整合使用计算分析模拟健康影响的多omic,现象和生活方式数据.

主要成果:

这项研究正在进行中,结果正在等待.
数据收集包括基线,一年和两年的随访.
分析将重点关注肠道微生物组调解心血管疾病风险,随着内分泌特征的变化.

结论:

预计这些发现将阐明心血管疾病发展中的性别特异性机制.
这项研究可能会为CVD的新型预防和治疗策略提供信息.
了解宿主-微生物组-激素相互作用对于个性化心血管医学至关重要.

关键词:

生物技术和生物信息学心血管疾病心血管疾病微生物学微生物学分子生物学分子生物学营养营养营养营养营养变性人变性人变性人

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