纳米配方Pyraclostrobin与铁胺增强有效利用活性成分和提高生物安全
Fengcheng Huang1, Tianyu Zhang2, Lisong Zhu1
1Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, P. R. China.
Chemistry & biodiversity
|January 9, 2025
概括
与纳米铁甲酸 (FeBi) 配合的纳米配制的皮拉克洛斯特罗宾 (PYR) 提高了杀菌剂的效率,降低了毒性. 这种可持续农业方法改善了疾病控制和活性成分的利用.
科学领域:
- 农业科学 农业科学
- 纳米技术纳米技术
- 植物病理学 植物病理学
背景情况:
- 皮拉克洛斯特罗宾 (PYR) 是一种广泛使用的具有低利用效率的斯特罗比素杀菌剂,需要改善可持续农业的配方.
- 优化杀菌剂的使用对于提高作物保护和最小化环境影响至关重要.
研究的目的:
- 开发和评估使用纳米铁木化物 (FeBi) 的纳米配制皮拉克洛斯特罗宾 (PYR/FeBi NPs),以提高有效性和安全性.
- 研究新型PYR/FeBi纳米颗粒的抗Botrytis活性和潜在机制.
主要方法:
- 使用闪光纳米沉来合成球形PYR/FeBi纳米粒子 (NP).
- 进行了体外和体内研究,以评估番茄植物对Botrytis cinerea的抗真菌活性.
- 机械学研究研究了线粒体代谢和细胞损伤的破坏.
- 细胞毒性测试是在人类和仓鼠细胞系上进行的.
主要成果:
- PYR/FeBi NPs表现出稳定的药物负载 (67.9%) 和受控释放,具有增强的抗Botrytis活性.
- 在体内,PYR/FeBi NP在番茄叶上的Botrytis cinerea的治疗和保护效率达到了90%以上,并且在幼苗上显著减少了灰菌病.
- 增强的活性与线粒体新陈代谢,乙化和氧化酸盐生产的更大破坏有关.
- 与商业上市的pyraclostrobin悬浮缩物 (PYR SC) 相比,PYR/FeBi NP的细胞毒性降低.
结论:
- 纳米配制的PYR/FeBi NP为可持续农业中有效利用杀菌剂提供了一个有希望的战略.
- 增强的疗效和减少PYR/FeBi NP的细胞毒性突出显示了它们在改善作物保护和环境安全方面的潜力.
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