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Updated: Jun 3, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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对异形特异性RAS-PI3Kα相互作用的结构见解以及RAS在PI3Kα激活中的作用

Daniel Czyzyk1, Wupeng Yan1,2, Simon Messing1

  • 1NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Nature communications
|January 9, 2025
PubMed
概括

通过激活PI3K-AKT-mTOR通路,RAS和PI3Kα突变驱动癌症. 这项研究揭示了RAS-PI3Kα相互作用的结构基础,为异型特异性癌症抑制剂提供了标.

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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

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