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相关概念视频

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

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Publisher Correction: Surface expression of antitoxin on engineered bacteria neutralizes genotoxic colibactin in the gut.

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相关实验视频

Updated: Jun 19, 2026

Porphyromonas gingivalis as a Model Organism for Assessing Interaction of Anaerobic Bacteria with Host Cells
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在生理学上相关的牙组织模型中强调长期宿主微生物群相互作用.

M Adelfio1, G E Callen1, A R Diaz1

  • 1Department of Biomedical Engineering, University of Massachusetts Lowell, Lowell, 01854, MA, USA.

NPJ biofilms and microbiomes
|January 9, 2025
PubMed
概括

这项研究开发了一种新的人类口腔组织模型,以观察宿主微生物群相互作用. 该模型成功地维持了口腔组织和微生物群落的健康7天,为新的口腔健康策略铺平了道路.

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Assessing the Viability of a Synthetic Bacterial Consortium on the In Vitro Gut Host-microbe Interface
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Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
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Last Updated: Jun 19, 2026

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科学领域:

  • 微生物学 微生物学
  • 口腔生物学 口腔生物学
  • 组织工程是组织工程.

背景情况:

  • 口腔是病原体的储存库,了解宿主微生物群相互作用对于各种疾病状态至关重要.
  • 传统的培养方法难以复制牙周的复杂牙结构和生理特征.

研究的目的:

  • 在健康条件下研究宿主微生物群相互作用,使用一种新的人类口腔组织模型.
  • 在七天内评估宿主组织和微生物群落的生存能力和功能.

主要方法:

  • 开发和利用一个体外人类口腔组织模型.
  • 在七天的时间内监测宿主微生物群相互作用.
  • 评估宿主屏障完整性,功能反应和微生物社区动态.

主要成果:

  • 实验室模型证明了宿主组织和微生物群体的长期生存能力.
  • 保存了宿主屏障完整性和表型功能反应.
  • 保持了健康的微生物种群和细菌间的交流.

结论:

  • 开发的体外平台成功地维持了牙周位内的组织稳态.
  • 这个模型为识别预测性口腔疾病生物标志物提供了有价值的工具.
  • 该平台可以帮助制定新的干预策略,以促进口腔和整体健康.