带有内部消散的顶点模型使持续的流量成为可能
Jan Rozman1, Kvs Chaithanya2,3, Julia M Yeomans4
1Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford, UK.
Nature communications
|January 9, 2025
概括
这项研究引入了一种新的组织流动模型,用内部粘性消散代替基板摩擦. 这允许有组织的集体细胞迁移和组织动态,这对早期胚胎发育至关重要.
科学领域:
- 生物物理学的生物物理.
- 发育生物学 发展生物学
- 细胞力学 细胞力学
背景情况:
- 表皮组织流动是由复杂的细胞内和细胞间机械力驱动的.
- 细胞形状异质性或阴性秩序越来越多地被认为是其在组织动态中的作用.
- 许多早期胚胎表现出由基质不支持的表皮质,其中内部粘性消散占主导地位.
研究的目的:
- 通过结合内部粘性散射来扩展活跃的阴性顶点模型.
- 调查长距离速度相关性和上皮组织中的时空组织的出现.
- 将细胞水平的顶点模型与连续性的活体体质联系起来,以了解组织流动.
主要方法:
- 开发了一个活跃的内马特顶点模型.
- 替代了基板摩擦与内部粘性消散.
- 模拟的上皮层被限制在一个通道.
主要成果:
- 内部粘性消散,再加上细胞形状异构性,使得长距离的速度相关性成为可能.
- 在封闭的上皮层中证明了持续的组织流动.
- 显示了高度组织的时空流动的自发出现.
结论:
- 内部粘性消散是产生无基质上皮质中组织组织流的关键因素.
- 该模型提供了细胞层次动态和连续性活跃分子学之间的机制联系.
- 这种机制可能解释了在形态发生过程中观察到的大规模集体细胞迁移.
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