基于empagliflozin的四重口服治疗2型糖尿病:一个前性队列研究
Fatemeh Moosaie1,2,3, Shiva Abedinzadeh1, Soghra Rabizadeh1
1Endocrinology and Metabolism Research Center (EMRC), School of Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran.
Scientific reports
|January 9, 2025
概括
将empagliflozin添加到三重口服低血糖药物治疗中,可以有效地控制2型糖尿病 (T2DM). 大多数患者实现了目标HbA1c,在七年内,血糖控制和心脏代谢参数显著改善.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2DM) 管理具有挑战性,因为在三重口服低血糖剂 (OHA) 治疗中血糖控制不佳.
- 不愿启动胰岛素治疗的患者需要使用替代治疗策略.
研究的目的:
- 评估在T2DM患者中添加empagliflozin在四倍OHA治疗方案中的长期有效性,患者的血糖水平不受控制.
- 评估empagliflozin对血糖控制,体重,脂质概况和血压的影响.
主要方法:
- 一项前性队列研究,涉及575名未经控制的T2DM成年患者,接受三重OHA治疗.
- 随访期为7年 (68个月),评估血糖参数,体重,BMI,腰围,脂质概况和血压.
- 恩帕格利弗洛辛被添加到现有的三重OHA治疗方案中,用于不愿使用胰岛素的患者.
主要成果:
- 92.5%的患者达到目标HbA1c水平 (<7%).
- 观察到HbA1c,体重,BMI,总胆固醇,LDL,甘油三,DBP和MAP的显著降低.
- 腰围和HDL水平没有显著变化;SBP保持相对稳定.
结论:
- 将empagliflozin添加到多个OHA是T2DM中长期血糖管理的有效策略.
- 恩帕格利弗洛辛在心脏代谢方面具有显著的益处,为选定的患者提供了胰岛素治疗的有希望的替代方案.
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