在阿里皮普拉和脱水阿里皮普拉的血度ABCB1多态的影响
Francisco José Toja-Camba1,2,3, María Vidal-Millares4, María José Durán-Maseda4
1Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), 15706, Santiago de Compostela, Spain.
在ABCB1基因的遗传变异显著影响阿里皮普拉 (ARI) 的新陈代谢和血水平. 特定的ABCB1基因型与改变的ARI/脱水阿里皮普拉比率相关,影响治疗反应.
科学领域:
- 药物基因组学 药物基因组学
- 药物新陈代谢 药物新陈代谢
- 神经科学是一个神经科学.
背景情况:
- 阿里皮普拉 (ARI) 是一种非典型的抗精神病药.
- 由ABCB1编码的P-葡萄糖蛋白 (P-gp) 影响药物排出.
- 每月一次的阿里皮普拉 (AOM) 改善了患者的遵守.
研究的目的:
- 研究ABCB1单核酸多态 (SNPs) 对ARI和脱水利皮醇 (DHA) 度的影响.
- 评估ABCB1变异对接受AOM的患者ARI/DHA比率的影响.
- 考虑CYP2D6和CYP3A4与P-gp效应相关的作用.
主要方法:
- 三种流行的ABCB1SNP (G2677T,C3435T,C1236T) 的基因定型.
- 在AOM治疗的患者中测量血ARI和DHA度.
- 基于已识别的基因型和单元型的ARI/DHA比率的分析.
主要成果:
- 在ABCB1基因型/半型和ARI/DHA比率之间发现了显著的关联.
- 与TT相比,GG基因型在G2677T中的ARI/DHA比率大约是TT的两倍.
- 突变T等位基因的增加与较低的ARI和较高的DHA度相关.
结论:
- ABCB1基因变异显著影响阿里皮普拉的处置.
- 基因定型ABCB1,以及CYP2D6和CYP3A4,可能有助于监测ARI血度.
- 药物遗传学分析可以个性化阿里皮普拉治疗策略.
更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
相关概念视频
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Hepatic Drug Clearance: Effect of Protein Binding
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
Factors Affecting Drug Response: Overview
Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Factors Influencing Drug Absorption: Disease States and Pharmacology
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Factors Affecting Drug Biotransformation: Biological
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
