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Updated: Jun 3, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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在HPV阳性细胞中,DARPin诱导的p53的重新激活

Philipp Münick1, Alexander Strubel1, Dimitrios-Ilias Balourdas2,3

  • 1Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany.

Nature structural & molecular biology
|January 9, 2025
PubMed
概括

一种新设计的蛋白质可以阻断人乳头瘤病毒 (HPV) 基蛋白E6和E7,并重新激活瘤抑制剂p53. 这种方法显示了通过稳定p53并恢复其功能来预防HPV驱动的癌症的潜力.

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