在双相情感障碍中,多式神经成像和临床,认知和日常功能特征之间的多变量模式
Viktoria Damgaard1,2, Lydia Fortea3,4, Johanna M Schandorff1,2
1Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Mental Health Services, Capital Region of Denmark, Frederiksberg, Denmark.
概括
研究人员确定了与双相情感障碍 (BD) 认知表现相关的脑成像模式. 这一发现可能会导致针对大脑活动的新疗法,以改善BD患者的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 双极性障碍 (BD) 在临床,认知和功能领域呈现出显著的异质性,使诊断和治疗复杂化.
- 识别可靠的基于大脑的生物标志物对于分层患者和开发针对BD的向疗法至关重要.
研究的目的:
- 采用数据驱动的多变量方法来探索多式神经成像特征与 BD 个体的行为表型之间的联系.
- 发现潜在的基于大脑的生物标志物,用于患者分层和双相情感障碍治疗干预.
主要方法:
- 使用正规相关性分析 (CCA) 来检查167名BD患者的56种成像和23种行为变量之间的关系.
- 结构和功能磁共振成像 (MRI) 数据,以及临床,认知和功能评估被整合在一起.
- 来自46个健康对照组的数据被纳入标准化和比较分析.
主要成果:
- 在BD患者的成像和行为数据集之间发现了显著的正统相关性 (r=0.84,p=0.004).
- 认知表现,特别是心理运动速度,口头记忆和口头流性,与背侧前额叶皮质和上边环状回路中的基于任务的激活模式密切相关.
- 即使控制其他临床和日常功能变量时,这些关联仍然很重要.
结论:
- 背部前额头和头顶认知控制区域的基于任务的激活是双相情感障碍的亲认知干预的有希望的目标.
- 多模式神经成像与行为数据相结合,提供了一种强大的方法来理解BD异质性.
- 这项研究突出了大脑活动调制作为BD认知缺陷的治疗策略的潜力.
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