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Published on: May 8, 2012
动脉瘤圆顶和血管压力测量,包括卷曲,支架辅助卷曲和流量转移
Timothy A Becker1, Kailey L Lewis1, Holly F Berns1
1Mechanical Engineering Department, Northern Arizona University, Flagstaff, AZ, USA.
内血管治疗,如卷积和流量转移,对内动脉瘤压力影响最小. 与预期相反,破坏动脉瘤内的血液流动不会显著改变动脉瘤内压力.
科学领域:
- 生物医学工程 生物医学工程
- 医疗器械技术 医疗器械技术
- 神经外科 神经外科
背景情况:
- 内动脉瘤的内血管治疗结果的变化引发了关于血液动力学影响的问题.
- 虽然内血管技术改变了血液流动和剪切,但它们对动脉内压力的影响尚不清楚.
- 了解压力效应可以改善结果预测和治疗指导.
研究的目的:
- 调查内血管治疗对动脉内压力的影响.
- 为了量化卷轴,支架辅助卷轴和流量转移器放置期间和之后的压力变化.
- 为了比较不同动脉瘤大小和临时气球闭塞的压力动态.
主要方法:
- 使用紫外线固化材料创建了带有室内压力龙头的3D打印动脉瘤模型.
- 一个带有脉动式的流量系统模拟了用血液模拟液体模拟生理条件.
- 在模拟的内血管干预 (卷轴,支架,流量转移,气球封闭) 期间记录了实时压力.
主要成果:
- 与对照组相比,卷圈和流量转移器的放置导致了最小的动脉内压力变化 (<5%).
- 流量转移器的放置显著减少了动脉内流量,有三个设备几乎中断了流量.
- 暂时气球封闭增加了近位压力 (9%) 和远位压力下降 (14%),减轻了动脉瘤内压力.
结论:
- 内血管治疗,如卷积和流量转移,会导致动脉内压力的微不足道变化.
- 单单是动脉内流动的干扰不会显著影响动脉内压力.
- 需要进一步的研究来了解血液动力学和治疗结果之间的复杂关系.
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