相关实验视频

Updated: Jun 3, 2025

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

Published on: October 11, 2018

抗生素和抗微生物对生长表现,肠道形态,肠道损伤得分,皮质微生物计数和免疫状况的比较影响在被死肠炎挑战的肉中

Muhammad Muneeb¹, Ehsaan Ullah Khan¹, Mubashar Ali¹

¹Department of Animal Nutrition, Faculty of Animal Production and Technology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Probiotics and antimicrobial proteins

|January 9, 2025

概括

抗微生物 (AMP) 在300克/有效地减轻肉死肠炎 (NE),改善生长和肠道健康. 这表明AMP是抗生素增长促进剂 (AGP) 的可行替代品,用于应对NE挑战.

科学领域:

禽畜科学禽畜科学禽畜科学
动物营养动物营养
微生物学微生物学

背景情况:

死亡性肠炎 (NE) 对肉的健康和生产力构成重大威胁.
抗生素增长促进剂 (AGPs) 是常用的,但面临着越来越多的监管审查.
抗微生物 (AMP) 正在成为AGP的潜在替代品.

研究的目的:

为了比较抗微生物 (AMP) 与常规抗生素增长促进剂 (AGP) 在患有死肠炎 (NE) 的 brojlers 中的疗效.
评估不同的AMP含量水平对肉的表现,健康和肠道完整性的影响.

主要方法:

720只公被分为五个治疗组:未感染的对照,感染的对照,感染的+AGP,感染的+200g/AMP,感染的+300g/AMP.
使用菌疫苗接种和随后的Clostridium perfringens口服输液诱导NE.
在35天内评估了鸟类的表现,NE病变得分,菌体卵泡流失,肠道形态,肠道微生物群,免疫器官体重和抗体标位.

主要成果:

在非挑战和挑战阶段,每300克的AMP补充剂显著改善了体重增加和料转换比率 (FCR).
与受感染的对照组相比,300克/AMP组表现出增强的生存能力,降低了NE病变得分,以及降低了菌卵囊流失.
AMP积极影响了肠道形态,肠道微生物平衡,免疫器官体重和对纽卡斯尔病的抗体标位.

结论:

抗微生物 (AMP) 在300克/有效地减轻肉死肠炎 (NE).
在NE挑战期间,AMP在 brojiler饮食中显示出作为抗生素生长促进剂 (AGPs) 的可行替代品的潜力.
对AMP的进一步研究可以通过减少对常规抗生素的依赖来促进可持续的肉生产.

关键词:

在C. perfringensens中使用.抗生素替代品抗生素替代品抗微生物是一种抗微生物.牛肉是什么意思牛肉是什么意思死亡性肠炎 (necrotic enteritis) 是一种死后肠炎.

更多相关视频

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Author Spotlight: Enhancing Understanding and Treatment Strategies with the NEC-on-a-Chip Model

Published on: July 28, 2023

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

相关概念视频

Biological Methods for Microbial Control

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...