代谢综合症和风湿性疾病之间的遗传共同点通过疾病互动体模块
Yinli Shi1, Shuang Guan1, Xi Liu1
1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Journal of cellular and molecular medicine
|January 9, 2025
概括
代谢综合征 (MetS) 与类风湿性关节炎等类风湿性疾病有着共同的遗传联系. 识别这些共同的基因为新的,共享的治疗策略提供了潜力.
科学领域:
- 遗传学 是一个遗传学.
- 系统生物学 系统生物学
- 类风湿病学 类风湿病学
背景情况:
- 代谢综合征 (MetS) 和类风湿性疾病经常同时发生,这表明潜在的共享生物机制.
- 全基因组关联研究 (GWAS) 已经确定了MetS和各种类风湿性疾病的遗传风险因素.
研究的目的:
- 使用疾病互动组网络调查代谢综合征 (MetS) 和类风湿性疾病之间的遗传共同点.
- 确定共享的基因和途径,将MetS与类风湿性关节炎 (RA),结性脊柱炎 (AS),全身性红斑狼 (SLE) 和Sjogren综合征 (SS) 联系起来.
主要方法:
- 在大型GWAS数据上利用了链接不平衡得分回归,交叉特征元分析和同地化分析.
- 构建并分析了一种具有模块分区的疾病互动组网络,以量化蛋白质-蛋白质相互作用.
- 进行了Mendelian随机化分析以求因果推断,并使用临床样本验证了映射基因.
主要成果:
- 在MetS和RA,AS,SLE和SS模块网络之间确定了显著的遗传相关性和拓重叠.
- 功能分析揭示了参与代谢途径,炎症,自和细胞因子调节的共同目标.
- 确认了MetS表型与类风湿性疾病之间的因果关系,独立于酒精和吸烟.
结论:
- 在MetS和主要的类风湿性疾病之间建立了特定的遗传关联和分子共同点.
- 突出了PRRC2A,PSMB8,BAG6,GPSM3和PBX2等基因作为共享治疗干预的潜在目标.
- 这些发现为了解遗传因素在代谢和自身免疫/炎症条件中的类效应提供了基础.
更多相关视频
07:35A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
1.6K
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
375
相关概念视频
Genome-wide Association Studies-GWAS
12.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.4K
The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
Autoimmune Disorders
385
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
385
Interactions Between Signaling Pathways
6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Proteoglycans
3.9K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.9K
T Cell Types and Functions
946
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
946
