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大脑铁沉积和脑小血管疾病患者的认知衰退:一个定量敏感性测绘研究

Yian Gao^1,2, Changhu Liang¹, Qihao Zhang³

¹Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-wu Road, Jinan, 250021, China.

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概括

铁沉积在大脑中的沉积.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
医学物理医学物理

背景情况:

定量灵敏度测绘 (QSM) 不侵入性地评估大脑的铁水平.
铁的积累与正常衰老和各种病理有关.

研究的目的:

在脑小血管疾病 (CSVD) 患者和健康对照者之间,比较大脑灰质核中的铁沉积量.
研究影响CSVD中铁沉积和认知功能的因素.

主要方法:

321名受试者进行了认知测试 (Stroop Color Word Test) 和MRI (多声梯度回声序).
使用形态启用双极反转 (MEDI+0) 生成QSM地图.
在严重的CSVD,轻度至中度的CSVD和健康的对照组中比较了深灰色物质敏感度值和认知功能.

主要成果:

在各组之间发现了Stroop分数和敏感度值 (白球,面,尾状核) 的显著差异.
年龄,糖尿病和吸烟对基底腺核中的铁沉积产生了积极的影响.
神经体铁沉积部分介导了高血压和认知功能之间的关系.

结论:

年龄,糖尿病和吸烟与基底腺铁沉积增加和认知能力下降有关.
调查结果有助于理解和管理CSVD.

关键词:

大脑小血管疾病大脑小血管疾病认知障碍认知障碍是一种认知障碍.定量敏感性映射测绘定量敏感性映射测绘在Stroop色彩词测试中使用Stroop色彩词.总的CSVD分数是多少

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