在关节动脉支架后定义有意义的健康状况变化值
Jonathan Kluger1, Gaëlle Romain2, Carlos Mena-Hurtado2
1Yale School of Medicine, New Haven, Connecticut, USA.
概括
确定了转门动脉支架 (TF-CAS) 的最小临床重要差异 (MCID). 虽然20-30%的患者在TF-CAS后表现出改善的健康状况,但大多数患者在30天后没有变化或恶化.
科学领域:
- 血管外科 血管外科
- 健康 结果 研究 研究 结果
- 干预心脏病学 干预心脏病学
背景情况:
- 在转关节动脉支架 (TF-CAS) 后评估健康状况的变化对于评估成功至关重要.
- 对于TF-CAS后的健康状况,临床重要最小差异 (MCID) 在很大程度上是未知的.
- 这项研究旨在定义MCID并量化TF-CAS后的健康状况变化.
研究的目的:
- 为了确定TF-CAS.后的健康状况的临床重要差异 (MCIDs) 的最小值.
- 量化健康状况改善或恶化的比率在TF-CAS后30天.
- 为了利用来自"Endarterectomy (SAPPHIRE) 高风险患者的保护性支架和血管造形术" (SAPPHIRE) 注册表的数据.
主要方法:
- SAPPHIRE注册数据 (2010-2014) 包括接受TF-CAS.的患者.
- 在基线和30天使用SF-36 (2010-2012) 和EQ-5D (2012-2014) 评估健康状况.
- 计算了基于分布的MCID (0.5 * SD基线),并将变化分类为改善,不变或恶化.
主要成果:
- 评估了3930名 (EQ-5D) 和3018名 (SF-36) 患者的健康状况.
- 确定了加权的MCIDs:0.09 (EQ-5D指数),11.00 (VAS),4.70 (PCS) 和5.40 (MCS). 它们可以分别为0.09 (EQ-5D指数),11.00 (VAS),4.70 (PCS) 和5.40 (MCS).
- 在30天后,21.2%-26.1%改善,10.5%-16.7%恶化,57.2%-66.1%保持不变.
结论:
- 在使用通用仪器确定了TF-CAS后健康状况有意义变化的门.
- 大约70%-80%的患者在TF-CAS后30天的健康状况没有变化或恶化.
- 一种针对动脉疾病的特定仪器可以更好地了解TF-CAS对患者健康状况的影响.
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