微核数与男性不育相关:对染色体异常和生殖参数的临床分析
Shun-Han Zhang1, Ying-Jun Xie, Wen-Jun Qiu
1Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China.
Asian journal of andrology
|January 10, 2025
概括
微核 (MNi) 在不育男性中显著增加,与精子质量和数量下降相关. 这一发现表明,MNi可能成为诊断男性不育并了解其进展的有价值生物标志物.
科学领域:
- 生殖生物学 生殖生物学
- 临床遗传学 临床遗传学
- 安德罗学与人类学
背景情况:
- 男性不孕症影响着人口的很大一部分,其潜在原因复杂.
- 微核形成 (MNi) 是染色体不稳定性和DNA损伤的指标.
- 了解MNi和男性不孕症之间的联系可以改善诊断方法.
研究的目的:
- 研究微核形成与男性不孕不育的各种参数之间的相关性.
- 评估MNi作为男性生殖健康诊断生物标志物的潜力.
- 探索MNi与不孕男性遗传异常之间的关系.
主要方法:
- 招募了2252名男性患者,收集精液参数和临床数据.
- 对性别染色体异常 (X和Y染色体) 进行遗传分析.
- 在外周血液样本上进行细胞动力阻断微核 (CBMN) 查.
- 为了分析,参与者被分为常态动物精子症和非常态动物精子症组.
主要成果:
- 在不育男性中观察到显著更高的MNi水平,包括那些患有亚精子症的男性,与常态亚精子控制组相比.
- MNi的存在与精子度,运动率的降低以及精子异常形态的增加显著相关.
- 在亚精子男性中,遗传和非遗传组之间没有发现MNi的显著差异.
结论:
- 微核 (MNi) 与男性不孕症和精液质量受损有着强烈的关联.
- MNi可以作为男性不孕不育的潜在诊断工具.
- 需要进一步的研究来阐明将MNi与男性不孕症联系在一起的机制.
相关概念视频
01:23Infertility in Males
241
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
241
01:43Sex-linked Disorders
100.3K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
100.3K
01:21Nondisjunction
3.7K
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
3.7K