甲状腺癌幸存者的怀孕:甲状腺切除术和放射性是否重要?
Chung-Jen Teng1,2,3, Chiu-Mei Yeh2,4, Chia-Jen Liu2,3,4,5
1Division of Oncology and Hematology, Department of Medicine, Far Eastern Memorial Hospital, No. 21, Sec. 2, Nanya S. Road, Banqiao District, New Taipei City 22060, Taiwan.
Postgraduate medical journal
|January 10, 2025
概括
甲状腺癌的治疗方法,如甲状腺切除术和放射性治疗,不会影响年轻女性的怀孕率. 年龄是影响怀孕的最重要因素,年轻女性在治疗后生育率更高.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 生殖医学 生殖医学
背景情况:
- 甲状腺癌主要影响年轻女性,引发了人们对治疗后生育能力保护的担忧.
- 标准治疗包括甲状腺切除术和放射性 (RAI) 治疗,需要了解它们对生殖的影响.
研究的目的:
- 研究甲状腺切除术和RAI治疗对年轻女性甲状腺癌患者怀孕概率的影响.
- 确定影响该人口群体诊断后生育能力的关键因素.
主要方法:
- 一项全国性的基于人口的研究利用了台湾国家健康保险研究数据库 (2000-2017年).
- 使用逻辑回归和Cox比例风险模型分析了45岁以下的甲状腺癌妇女的怀孕概率.
- 评估了甲状腺切除术和RAI治疗对妊娠结果的影响.
主要成果:
- 在一个由10937名甲状腺癌患者组成的队列中,甲状腺切除术和RAI治疗没有降低怀孕的可能性.
- 年龄是最关键的因素,30岁以上的女性怀孕概率明显降低.
- 与糖尿病并发症和更高的社会经济地位与降低怀孕可能性有关.
结论:
- 甲状腺切除术和RAI治疗不会降低被诊断为甲状腺癌的年轻女性怀孕的可能性.
- 年龄是生育能力的主要决定因素,年轻女性表现出更高的受孕率.
- 研究结果支持针对年轻女性患甲状腺癌的个性化生育咨询和治疗计划.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.2K
Radiological Investigation I: X-ray and CT
206
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
206
Biological Effects of Radiation
15.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.3K
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Radiological Investigation III: Pulmonary Angiogram and PET Scan
82
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
82
Isotopes and Radioisotopes
8.3K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
An isotope containing...
8.3K


